Why atrial fibrillation Antithrombotic

Heart as a pump, each throb will pump blood to the body for the whole body tissues and organs to provide oxygen and nutrients. The heart of this mechanical activity is affected by electrical activity of control and domination, and normal circumstances, the electrical activity from the atrium at the sinoatrial node, sinus node issued the law of electrical pulses, 60-100 times per minute to various parts of the heart conduction , caused by various parts of the order of contraction of the heart (atrium to ventricle). Atrial fibrillation, the heart's electrical activity is no longer dominated by the sino-atrial node was atrial rapid, chaotic electrical activity of alternative corresponding ventricular fast but not the law of systolic and diastolic. There is a reason the majority of atrial fibrillation, such as rheumatic heart disease, coronary heart disease, hypertension, hyperthyroidism, such as more performance for persistent atrial fibrillation, there are a small number of those who can not find the reasons, known as atrial fibrillation in isolation.

According to statistics, the atrial fibrillation group of about 4 percent of adults, 40-year-old began to increase after the occurrence of atrial fibrillation, 65-year-old began after a significant increase. The incidence of atrial fibrillation in the elderly about 7-14%.

Atrial fibrillation when the cardiac output reduced by a quarter or even 50 percent, in particular the existence of ventricular function at the same time there is damage. Atrial fibrillation can be induced or exacerbated heart failure and pulmonary edema, induced myocardial ischemia. Atrial contraction due to the loss of ability to easily lead to atrial thrombosis, caused by cerebral embolism after falling or other peripheral vascular embolization. Atrial fibrillation is an independent risk factor for stroke, atrial fibrillation patients with ischemic stroke average annual incidence of 5 percent, accounting for 10% of cerebral -15%; there Nonvalvular atrial fibrillation patients, there is the risk of cerebral embolism 5-7 times without atrial fibrillation, when the heart valve disease (such as rheumatic heart disease), occurred in a higher percentage. Atrial fibrillation caused by stroke with high mortality and disability to the patient, family and community spirit and a great financial burden.

According to five large-scale clinical trials (AFASAK, SPAF, BAATAF, CAFA, SPINAF) comprehensive analysis reports, can be dense set of long-term oral (warfarin) to reduce the incidence of atrial fibrillation patients with stroke by 68%, where appropriate, to monitor the situation Under the bleeding does not increase the incidence of atrial fibrillation patients is an effective measure for preventing stroke.

Oral anticoagulant drug greatest worry is bleeding worried, therefore, on blood coagulation monitoring is essential purpose is to guarantee the efficacy of anti-thrombosis At the same time, to avoid the occurrence of bleeding. In recent years the international community to adopt prothrombin time / international normalized ratio (PT / INR) monitoring can be set Micronesia medication, facts have proven that the incidence of bleeding was not significantly higher than oral aspirin.

Our own experience is that the anticoagulant (thrombosis prevention and treatment) out-patient beds next to PT / INR monitoring (Hemochron), is to improve the antithrombotic effect of warfarin, to ensure patient safety of effective measures, combined with a variety of ways for patients and public education, also improve patient medication compliance, and enhance affordability and psychological resistance of self-confidence.

Some people tried abroad anticoagulant warfarin self-management, patients were randomly divided into 179 cases of their own at home measured INR (CoaguCheka) regulation and conventional dosage of warfarin treatment, resulting in an exciting, inadequate anticoagulation reduced quality of life of patients improved satisfaction with the increase, but be prudent in domestic applications, must be the guidance of experienced doctors and patients or their family well-trained manner.